Tryptomer, is it safe? uses,side effects, dosage

What is Tryptomer?

Tryptomer is the brand name of an oral tablet which belongs to the tricyclic antidepressant (Tertiary Amine) group of medications. It is manufactured and marketed by Merind Ltd. (Wockhardt Ltd). It is available in the packaging of ten tablets per strip in case of 10 mg strength of the salt, single tablet in case of 25 mg strength of the salt & single tablet in case of 75 mg strength of the salt.

  1. What is the generic name(s)?
  2. How does it work ?
  3. What are it’s uses ?
  4. How effective is this medicine ?
  5. What are the Side Effects ?
  6. What is the Dosage ?
  7. What are the precautions I need to take ?
  8. Is it safe to take if I am pregnant ?
  9. Is it safe to take if I am breast feeding ?
  10. Can this medicine be given to children and infants ?
  11. Is Tryptomer available as an over the counter (OTC) product?
  12. Reference

 

Tryptomer - uses,side effects, dosage

Tryptomer – uses,side effects, dosage


What is the generic name (s)?

The generic name for Tryptomer is Amitriptyline. It is a tricyclic antidepressant (Tertiary Amine) and is present in three strengths of 10 mg , 25 mg  and 75 mg in this tablet’s case.

How does it work ?

The working of Tryptomer is to hinder the retaking up of Serotonin (5 HT) & Noradrenaline in the nerve terminals of the Central Nervous System.This produces antidepressant effect due to a higher concentration of neurotransmitters in the synaptic cleft . The generic of this medicine also has anticholinergic activity. This medicine more selectively hinders the retaking up of Serotonin than Noradrenaline.

Its effect starts within two to three weeks of its administration.The maximum duration of the effect of this medicine is around six weeks.

What are it’s uses ?

Tryptomer is used mainly in the management of the below mentioned medical conditions:

  • Depression
  • Prophylaxis of migraine
  • Bulimia nervosa (an eating disorder characterized by binge eating followed by purging)
  • Nocturnal enuresis(wetting of bed by urination, mostly of children, during sleep)
  • Neuropathic pain

How effective is this medicine ?

It is a very effective medicine for managing all the conditions mentioned above. Patient must follow doctor’s instruction on the time of administering, dosage and duration of the use of this medicine.

What are the Side Effects ?

The various side effects of Tryptomer are being listed below:

  • Constipation
  • Headache
  • Drowsiness
  • Arrhythmia
  • Galactorrhea
  • Loss of libidoConfusion
  • Dizziness
  • Difficulty in micturition
  • Anorexia
  • Urticaria
  • Blurred vision
  • Nausea
  • Agranulocytosis
  • Hypotension
  • Impotence
  • Jaundice
  • Loss of libido
  • Gynecomastia
  • Rash
  • Vomiting
  • Tachycardia
  • Dryness of mouth
  • Sedation

What is the Dosage ?

The dosage of Tryptomer varies both with the age of the patient and the type of medical condition for which the medicine is being used to manage.

The table* given below tries to cover all the cases broadly for the purpose of general understanding only:

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Type of Medical Condition Age of the patient Recommended Dosage* Method of administration
Depression Adolescants* (children of age greater than 16 years) 30-75 mg daily or in divided doses, preferably at bedtime. Oral
 Depression Adults To start with 50-75 mg daily in divided doses or as a single dose at night. If required, dosage can be slowly increased to 150 mg daily Oral
 Depression Elderly Persons 30-75 mg daily or in divided doses, preferably at bedtime. Oral
Prophylaxis of migraine Adults To start with 10 mg at bed time. Maintenance dosage being 50 to 75 mg Oral
Neuropathic pain Adults To start with 10-25mg, then the dosage can be slowly increased up to 75 mg daily, as per requirement Oral
Nocturnal enuresis Children of age between 12 – 16 years 25 to 50 mg , preferably taken 1 hour before going to bed at night (course of this medicine should not be more than 3 months) Oral
 Nocturnal enuresis Children of age between 6 to 10 years* 10 to 20 mg, preferably taken 1 hour before going to bed at night (course of this medicine should not be more than 3 months) Oral

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* – The above table is for the purpose of general understanding only. It should never be substituted for the dosage prescribed by the doctor. Please follow your doctor’s prescription. Do not self-medicate.

What are the precautions I need to take ?

Tryptomer should be used with caution with all the conditions mentioned below:

  • Allergy to Amitriptyline
  • Pregnancy
  • Lactation
  • Hyperthyroidism
  • Alcoholics
  • Patient with suicidalthoughts
  • Myocardial infarction
  • Tachycardia
  • Heart diseases
  • Old aged patients
  • Strokes (also can happen due to prolonged exposure to sun)
  • Angle closure glaucoma
  • History of urine retention
  • Increased intraocular pressure
  • Renal impairment
  • Hepatic impairment
  • Chest pain

This drug has to be withdrawn slowly.Please follow the instructions of your doctor for this.

Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment.

Never self-medicate.

Is it safe to take if I am pregnant ?

No, it is not safe to take this medicine during pregnancy. This can be harmful for the to be born baby.Please share your pregnancy status with your doctor if being prescribed by this medicine.

Is it safe to take if I am breast feeding ?

No, it is not safe to take this medicine if you are breastfeeding or are planning for breast feeding. Please  consult with your doctor thoroughly if being prescribed for this medicine, as while breastfeeding this can get mixed with the blood and get transferred to the baby/child. This can result into bad or harmful effects.

Can this medicine be given to children and infants ?

This medicine can be given to children under strict medical supervision.Please consult with a doctor regarding the dosage and duration of use of this medicine, as these factors vary a lot from patient to patient.

But, this medicine is strictly not to be given to infants .This medicine can not only be harmful but also dangerous for them. Please consult your doctor to understand more about the use of this medicine.


Is Tryptomer available as an over the counter (OTC) product?

No, Tryptomer is not available as an over the counter or OTC product. It is a prescription drug. When being prescribed ,please consult with the doctor regarding correct dosage, timing and duration of use of this medicine.

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